zum Directory-modus

Reduction of Carbonyl Groups to Methylene Groups

Wolff-Kishner Reduction: Introduction

Reaction principle

The first step in the Wolff-Kishner reduction is the conversion of a ketone with hydrazine into the corresponding hydrazone. Subsequently, base-catalyzed hydrogen migration followed by protonation yields the alkane. This reaction can be used to transform ketones and oxocarboxylic acids into the corresponding alkanes and carboxylic acids, respectively.

Example:

Reduction of acetophenone to ethylbenzene.

Fig.1
Page 3 of 8