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Reduction of Carbonyl Groups to Methylene Groups

Wolff-Kishner Reduction: Introduction

Reaction principle

The first step in the Wolff-Kishner reduction is the conversion of a ketone with hydrazine into the corresponding hydrazone. Subsequently, base-catalyzed hydrogen migration followed by protonation yields the alkane. This reaction can be used to transform ketones and oxocarboxylic acids into the corresponding alkanes and carboxylic acids, respectively.


Reduction of acetophenone to ethylbenzene.

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