Reduction of Carbonyl Groups to Methylene Groups
Reduction of Carbonyl Groups to Methylene Groups: Introduction
The reduction of carbonyl groups to the corresponding methylene groups is mainly carried out by two methods.
The Wolff-Kishner reduction is the second methodology. In this reduction, the carbonyl function is first converted into a hydrazone, followed by loss of nitrogen to form the methylene group. The Wolff-Kishner reduction is mainly used for the reduction of ketones and oxocarboxylic acids.