Reduction of Nitro Compounds to Amines
Reduction of Nitro Compounds to Amines: Laboratory Application
Quantitative analysis of nitro compounds by reduction with tin in hydrochloric acid
The nitro compound is heated with finely granulated tin in half-concentrated hydrochloric acid. Subsequently, the reaction mixture is diluted with a small amount of water. Unreacted starting material and non-basic products are extracted with ether. The aqueous phase is poured into an aqueous sodium hydroxide solution to generate the free amine. Separation is followed by purification.
The isolated amine is titrated with perchloric acid to determine mass equivalency.