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Reduction of Nitriles to Amines

Reduction of Nitriles to Amines: Introduction

Reaction prinicple

In the laboratory, the reduction of nitriles to primary amines is mainly carried out with metal hydrides. Industry, however, uses catalytic hydrogenation. During the reduction with metal hydrides, the transfer of two hydride ions is followed by hydrolysis to yield the corresponding amine.


In industry, the reduction of nitriles to amines is an important step in the synthesis of amines from carboxylic acids. For example, ethylamine is prepared this way.


Reduction of butyronitrile to butylamine.

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