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Reduction of Amides to Amines

Reduction of Amides to Amines: Selection of Reducing Agent

Amides can be reduced either by catalytic hydrogenation or with lithium aluminum hydride in polar protic solvents. Under the latter conditions, some amides might yield alcohols or aldehydes. Sodium borohydride does not react with amides. Borane and sodium in propane-1-ol are good reducing agents for primary, secondary and tertiary amides. However, sodium dimethylamine borohydride does not reduce secondary amides.

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