Oxidation of Methylene Groups to Carbonyl Groups
Oxidation of Methylene Groups to Carbonyl Groups: Experimental Procedure
Oxidation of tetralin to 1-tetralone.
A mixture of 750 acetic acid, 25 cobalt(II) acetate tetrahydrate and 30 cobalt(II) bromide hexahydrate in a 2- flask equipped with stirrer, thermometer and reflux condenser is vigorously stirred at 40. Oxygen is bubbled into the stirred mixture and a solution of 330 tetralin and 255 acetic acid anhydride is added dropwise within 30 . The temperature of the reaction mixture has to be kept at 40. Oxygen is absorbed at a rate of 1,200 per . After an additional 30 , the reaction is quenched with ice water and the product extracted with ether. The extract is washed with a cold solution of sodium carbonate, dried over magnesium sulfate and distilled. The yield is 62%.
In general, the preparation of carbonyl compounds in the laboratory is carried out either by oxidation or dehydrogenation of primary or secondary alcohols.