Oxidation of Aldehydes to Carboxylic Acids
Oxidation of Aldehydes to Carboxylic Acids: Experimental Procedure
The procedure for the oxidation with permanganate is as follows:
To a strongly stirred mixture of aldehyde, dichloromethane, water and phase transfer catalyst (1/75 of the volume of water) the double (molar) amount of potassium permanganate is added in portions. The temperature must be kept at 15 bis 20. The mixture is stirred until discoloration of the permanganate (maximal 3 hours). Precipitated manganese dioxide is dissolved in an aqueous solution of hydrogen sulfite. The organic layer containing the product is separated, dried over sodium sulfate, and the dichloromethane is subsequently removed on a rotary evaporator.