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Oxidation of Aldehydes to Carboxylic Acids

Oxidation of Aldehydes to Carboxylic Acids: Biological Importance

The enyzme dehydrogenase participates in the metabolism of alcohols. Special variations of this enzyme are histidinol and aldehyde dehydrogenases which form carboxylic acids from alcohols and aldehydes, respectively. The oxidizing agent in these transformations is NAD+ which is being reduced to NADH + H+ .

3D model: Alcohol dehydrogenase

3D model: Nicotinamide adenine dinucleotide (NAD)

The following scheme is illustrative for a non-covalent mechanism.


The scheme below represents a covalent mechanism.


Whether a reaction follows one or the other mechanism firstly depends on the nature of the enzyme and secondly on the type of aldehyde.

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