Baeyer-Villiger Oxidation: Experimental
In the laboratory, Baeyer-Villiger oxidation is carried out with oxidizing agents, such as peracetic acid or meta-chloroperbenzoic acid, in dichloromethane as the solvent. In difficult cases, if the migrating group is a primary alkyl group, for example, it has been proven advantageous to use peroxytrifluoroacetic acid. However, strongly acidic trifluoroacetic acid produced in the reaction can cause side reactions. Therefore, disodiumhydrogen phoshate is added as a buffer. The solution containing ketone, peracid and buffer is heated under reflux. The reaction is finished after approximately only 30 - 60 .
Undissolved salts are filtered and the filtrat is washed with sodium carbonate solution and dried.