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Baeyer-Villiger Oxidation

Baeyer-Villiger Oxidation: Introduction


  • Ketones
  • Organic peracids

Reaction principle

In this reaction, an oxygen atom is formally inserted adjacent to the carbonyl group of the ketone to form an ester. Cyclic ketones form lactones by ring enlargement.

In unsymmetrically substituted ketones, the oxygen atom is inserted between the carbon of the carbonyl group and the higher substituted C atom.


2D animation of the Baeyer-Villiger oxidation


Preparation of lactones from cyclic ketones

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