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Biosynthese von Niacin aus Tryptophan

Abb.1

An der Biosynthese beteiligte Enzyme: 1: Tryptophan-2,3-Dioxygenase EC 1.13.11.11 (Cofaktor: Häm) 2: Arylformamidase EC 3.5.1.9 3: Kynurenin-3-Monooxygenase EC 1.14.13.9 (Cofaktor: FAD) 4: Kynureninase EC 3.7.1.9 (Cofaktor: Pyridoxal-phosphat) 5: 3-Hydroxyanthranilat-3,4-Dioxygenase EC 1.13.11.6 (Cofaktor: Eisen) 6: Chinolinat-Phosphoribosyl-Transferase EC 2.4.2.19 (Cofaktor: Magnesium) 7: Nicotinat-Phosphoribosyl-Transferase (Cofaktor: Magnesium) 8: Nicotin-Amidase