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Subject - Biochemistry

Vimentin is a member of the intermediate filament family of proteins. Intermediate filaments are an important structural feature of eukaryotic cells. They, along with microtubules and actin microfilaments, make up the cytoskeleton. Although most intermediate filaments are stable structures, in fibroblasts, vimentin exists as a dynamic structure. Vimentin is used as a marker for mesodermally derived tissues, and as such can be used as an immunohistochemical marker for sarcomas.

Crystal Structure of a Human Vimentin Fragment

PDB-Code: 3KLT

Scientists have found that vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. They concluded that vimentin plays a significant role in supporting and anchoring the position of the organelles in the cytosol.

Vimentin is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions.