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Subject - Organic Chemistry

A protecting group is an organic group which functions as a temporary protection of a functional group against reactions with oxidizing agents and other reagents. The reaction only takes place at the desired (unprotected) site of the molecule.

For example, an amino group can be protected with a tert-butoxycarbonyl group (BOC group, drawn in red), thereby allowing the formation of a peptide bond only at other sites. After successful reaction, the BOC group can easily be removed, e.g. with trifluoroacetic acid.

Fig.1
Introduction of the Boc-Group to protect the amino group of an amino acid