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primary biliary cirrhosisZoomA-Z

Subject - Biochemistry, Medicine, Immunology

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver that causes scarring, fibrosis and finally cirrhosis. The inflammation starts with a slowly progressing destruction of the small bile ducts in the liver and proceeds to the whole organ. In the beginning, when the liver is still intact, the disease can be diagnosed by detection of autoantibodies against mitochondrial antigens (AMA).