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Subject - Immunology

Macrophages are large scavenger cells (phagocytes) that reside in tissues. They circulate in the bloodstream as monocytes, differentiating into macrophages when they enter the tissue. Macrophages “devour” dead cells as well as pathogens and foreign substances, especially those that have been marked by antibodies or components of the complement system. The macrophage's surface forms an indentation and encloses the foreign body (phagocytosis). Once inside the macrophage, the intruder is broken down and the pieces, consisting of 3-7 amino acids, are presented to the T helper cells in the major histocompatibility complex class II (MHC II).

See also: phagocytes

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