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Subject - Biochemistry, Immunology
Interferons (IFN) are cytokines generated by leukocytes, fibroblasts, and T lymphocytes; they demonstrate antiviral, antitumour, and immunostimulating effects. The α-interferons (IFN leukocytes) are pure proteins that are produced by monocytes that attack viruses, among others. The β and γ interferons (fibroblast IFN and immune IFN) are glycoproteins.
On the whole, interferons increase the activity of macrophages, natural killer cells, monocytes, granulocytes, and cytotoxic T lymphocytes in the organism. This inhibits virus replication; in addition, the degradation of viral and cellular RNA is stimulated.