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Hofmann productZoomA-Z

Subject - Organic Chemistry

Named after the German chemist August Wilhelm von Hofmann, the olefin with the smaller number of alkyl groups at the double bond formed by β-elimination, e.g. dehydrohalogenation, is called the Hofmann product.

In general, β-eliminations proceed regioselectivity and because of the lowered steric requirements in the transition state, the thermodynamically favored olefin (Saytzeff product) is formed. However, the use of more demanding bases and/or the choice of leaving group as well as solvents, can influence the regioselectivity and thereby increasing the yield of the Hofmann product, for example.


See also: β-elimination