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Subject - Biochemistry
Guanine is the trivial name for 2-amino-1,9-dihydropurin-6-one.
It has the molecular formula C5H5N5O. and a molecular mass of () of 151.13 .
Besides adenine, guanine belongs to the purine bases of nucleotides. Guanine is formed biosynthetically in organisms from basic building blocks, via different recycling pathways from purine derivatives or by acidic hydrolysis of the nucleoside . It ocurs as base in DNA as well as in RNA. Additionally, guanosine triphosphate GTP is an important supplier of energy in muscles and in the biosynthesis of proteins.
In DNA and RNA, guanine binds to the pyrimidine base uracil by forming two hydrogen bonds without destroying the geometry of the polynucleotide.through three hydrogen bonds. In addition, it can bind in RNA to
The derivatives 8-azaguanine and 6-thioguanine shows antineoplastic activity.