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Subject - Organic Chemistry

The term amide describes a group of compounds considered to be derivatives of ammonia in which one or more hydrogen atoms are replaced by inorganic or organic acid residues (acid amides) or metals (metal amides, ammonia salts, e.g. sodium amide (NaNH2).

Depending on the number of replaced hydrogen atoms, the resulting compounds are named primary, secondary or tertiary acid amides RCONH2, (RCO)2NH, (RCO)3N. Biomolecules mostly contain primary amides which are derived from carboxylic acids and primary amines and, characteristically, show the amido group R-CO-NH-R'. For example, the amino acids asparagine, glutamine and N-formylmethionine possess an amide group. Coupling between adjacent amino acids in proteins also is achieved by forming amide bonds (peptide bonds).

Recommended Learning Units

Reduction of Amides to AminesLevel 220 min.

ChemistryOrganic ChemistryReduction Reactions

This learning unit describes the reduction of amides to amines. The mechanism and applications of this reaction are introduced.