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Subject - Biochemistry, Genetics

Adenine is the trivial name for 7(9)H-purin-6-amine or 6-aminopurine.

The molecular formula is C5H5N5 and the molecular mass (Mr) is 135.13.

Structural formula of adenine

Adenine together with guanine forms the group of purine bases. It mainly exists as the base part of the nucleoside adenosine and is a main constituent of DNA and RNA. It also occurs as a monomer in the main intracellular energy transfer molecule adenosine triphosphate (ATP), as a constituent of the universal regulator cyclic adenosine monophosphate (cAMP) as well as in kinetin, zeatin, coenzyme A and vitamin B12 .

In DNA, adenine is always bound through two hydrogen bonds to the pyrimidine base thymine, which is substituted by uracil in RNA..

The biosynthesis of adenine proceeds through the parent adenosine which upon acid hydrolysis easily yields adenine. It is an important intermediate in the formation of uric acid and, therefore, plays a role in the disposal of excess nitrogen through the liver.